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These assays can help to distinguish whether blank nanocarrier is biocompatible and to evaluate the AX-DOX toxicity to tumor cells.
In vitro and in vivo reporter assays can help in this regard.
High-throughput enzyme activity assays can help alleviate experimental bottlenecks, but few generally applicable technologies are currently available.
Quantification of rearing behavior in conjunction with standard analgesic assays can help in gaining a better appreciation of true analgesic efficacy of experimental drugs.
Although increased IgG index or the presence of oligoclonal bands in the CSF support an MS diagnosis, and AQP4 antibody assays can help in the differential diagnosis process, there are still no specific biomarkers to confirm the diagnosis.
Melt-curve analysis done as an additional end-point step in dye-binding qPCR assays can help demonstrate assay specificity by revealing the existence of multiple amplicons, but cannot prevent or limit their formation.
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The assay can help to explain unexpected drug clearance profiles, loss of efficacy or safety events caused by immune complexes and guide further development.
Cell binding assay can help us to direct measure the viral attachment to host cells with or without the treatment of compounds.
As such the assay can help to understand how a certain histone code is established and interpreted.
The combined usage of the purified Cas9 protein and the T7E1 assay can help to validate candidate crRNAs for injection to choose efficient crRNAs in vitro and in vivo.
The T-SPOT.TB assay can help to distinguish subjects with latent TB infection (LTBI) from those vaccinated with Bacillus Calmette-Guerin (BCG) [ 5, 6], but cannot directly distinguish between subjects with active TB and LTBI [ 7, 8].
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