No trends were observed for the other 7 biomarkers assayed (data not shown).
Similar values as determined for K. oxytoca and S. maltophilia were obtained when the other species of Klebsiella and S. rhizophila were assayed (data not shown).
The frequency of γH2AX positive micronucleated cells ranged from 86 to 90% for either treatment throughout the doses assayed (data not shown).
The antibody responses in animals immunised only once with P. berghei irradiated sporozoites were much lower, nonetheless the same pattern of antibody reactivities was observed when their sera were similarly assayed (data not shown).
21 of the 34 genes, or ∼62%, showed statistically significant differential expression by q-PCR at p<0.05 or less, while injection of a control MO targeting the human globin gene, which would not be present in the mouse genome, did not alter expression of any of the genes assayed (data not shown).
In the BAC fxAR121 mice, however, the AR121Q protein levels between mice with full NLK expression and those with a 50% reduction in NLK are not significantly different across the population assayed (data not shown).
