Further, other assays will be required to identify and quantify the modified lipids and proteins [9], [45], [46] that are widely believed to accompany ARM progression.
Further high-resolution structures of p115GHR/CC and binding partner complexes combined with characterization of structure based mutants in cell-based assays will be required to understand how p115 carries out its tethering function.
This finding predicts that if autoantibodies are included in risk profiling, multiplexed assays will be required.
Analyses of additional Norrin mutants in biophysical and cellular assays will be required to verify the putative Lrp5/6 binding site.
As further molecular targets are discovered across disease sites, effective assays will be required to determine cancers' susceptibility to targeted treatment.
Although metagenomic approaches were used to quickly annotate various carbohydrate-active enzymes, functional assays will be required for confirmation, since sequence homology does not guarantee functional identity.
Indeed biology is not composed of single molecules, but networks of molecules, thus creative assays will be required to test multiple ncRNAs in cooperation.
This putative acid shows a structure similar to the epoxomicin proteasome inhibitor (epoxy group) but chemical assays will be required to confirm its synthesis.
Taken together, these data raise a question as to whether multiple assays will be required to assess the potential activity of EDCs.
