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IHC assay was performed using indicated primary antibodies.
Viability assay was performed using the Alamar Blue reagents71.
HI assay was performed using 0.5% turkey red blood cells in U-bottom 96 well plates.
A ChIP assay was performed using the Pierce Agarose ChIP kit as described previously23.
The Wnt assay was performed using a procedure modified from the BPS Bioscience protocol.
Cell count proliferation assay was performed using IncuCyte ZOOM system according to the manufacturer's protocol.
AhR-reported assay was performed using AhR Reporter Assay system (Indigo Biosciences).
Electrophoretic mobility shift assay was performed using LightShift Chemiluminescent EMSA kit (Pierce).
ChIP assay was performed using the SimpleCHIP enzymatic chromatin immunoprecipitation kit (Cell Signaling Technology, MA, USA) as described previously35.
TdT-mediated dUTP nick end labelling (TUNEL) assay was performed using In Situ Cell Death Detection Kit-TMR-Red (Roche).
Active Ras assay was performed using the Active Ras Pull Down and Detection kit from Thermo Fisher (Cat.No.16117).
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