Exact(13)
We review currently used tolerance assays, and examine the many parameters that affect assay outcomes.
However, preliminary experiments showed that the approach does not lead to interpretable results on large, diverse chemical data sets of assay outcomes, especially for external predictions.
The importance of this cannot be understated with more than 70 million substance descriptions, 28 million unique small molecules, 480,000 biological assays, and 110 million biological assay outcomes (results from a substance tested in an assay is considered an outcome).
Altogether, PubChem is a sizeable data system of more than 219 million substance descriptions, 89 million unique chemical structures, one million biological assays, and 230 million biological assay outcomes (where an outcome is the set of results from a substance being tested in an assay).
As of June 2012, PubChem contains more than 92 million substance descriptions, 32 million unique small molecules, 600 thousand biological assays, and 170 million biological assay outcomes (each outcome is a set of results from a substance being tested in an assay).
Specifically, we associate single-cell functional assay outcomes with distinct cell surface marker expression intensities.
Similar(47)
To evaluate the effect of age upon QuantiFERON-TB Gold-In-Tube (QFT-IT) assay outcome among children examined for latent tuberculosis infection (LTBI).
This result is consistent with the MTT assay outcome which shows better cell viability for alginate rather than PLGA in close system of in vitro (Hao and Wen 2010; Ibusuki et al. 2003).
The role of solubility as a determinant of assay outcome is also considered based upon each compound's cross-assay activity score for a collection of publicly available screening results.
It is therefore unclear how results from different assays compare, and what factors most significantly influence assay outcome.
Protocol variations in steps involving the culture of PBMC with antigen in ELISpot assays were suspected to have the greatest capacity to alter the assay outcome.
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