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And after the assassination, her whole life was gone.
But they also know it's politically ill-advised to challenge Ms. Kennedy's qualifications for office without expressing one's love of the Kennedy family; of the deep sadness felt by her father's assassination, her mother's early passing, and her brother's death.
Upon Prime Minister Benazir Bhutto's assassination, her teenager-son assumed the chairmanship of the Pakistan People's Party, the nation's largest political party, and her husband, a man known for corruption, was installed as the nation's president.
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Benazir Bhutto will be mourned on the anniversary of her assassination at her burial place in her family shrine in Garhi Khuda Bakhsh in Sindh and all over Pakistan.
Her assassination brought her rather unsettled life to a tragic end.
A public wave of sympathy after her assassination catapulted her Pakistan People's Party to power in the 2008 elections.
Siddiq also has a uniquely personal link to political assassinations – her grandfather, the first prime minister of Bangladesh, was killed, along with 19 members of her mother's family.
The younger woman's guilt over past misdeeds (including tacit complicity in the assassination of her husband by her lover) makes her fight for her religious freedom all the more poignant.
In this special edition of "20/20," Ms. Yousafzai, above, speaks with Diane Sawyer about her passion for learning amid threats, the moments leading up to the assassination attempt, her recovery and her new memoir, "I Am Malala".
Jackie Kennedy lived through her husband's gruesome assassination before her eyes -- a horrifying experience that later caused her to question her faith, as expressed in private letters she sent to a priest.
It's been 34 years since Sara Jane Moore stood on a sidewalk 40 feet away from the back door of the St. Francis Hotel in San Francisco with a gun in her hand and assassination in her heart.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com