Exact(6)
These items represent 2 aspects of trial quality, the internal validity of the trial and whether the trial contains sufficient statistical information.
While these aspects are important, we argue that other significant aspects of trial quality impinge upon the truthfulness of the findings: biological plausibility, reproducibility and generalisability.
118 119 Trial location has also been associated with trial outcome, 120 aspects of trial quality (eg, authenticity of randomisation 121), and generalisability.
Early trials 14 20 22 23 24 presented limited data on the key aspects of trial quality, such as randomisation and maintenance of blinding.
Further, it has been observed that certain aspects of trial quality influence effect size estimates and empirical evidence suggests that small studies are, on average, of lower quality [ 4].
It has been observed that certain aspects of trial quality may influence the estimates of effect size, 22 23 24 25 and empirical evidence suggests that small studies are, on average, of lower quality and this could induce asymmetry on a funnel plot.
Similar(54)
A further three trials did not provide sufficient information to assess this aspect of trial quality (MacIntyre 2003 AUS; Newell 2006 NPL; Zwarenstein 2000 ZAF).
A Radiographer Trial Implementation Group (RTIG) involving radiographers from all UK participating centres was established to co-ordinate clinical aspects of the trial quality assurance process.
We observed higher methodological quality of trials in our sample compared with a representative sample of trials indexed in PubMed, 44 therefore it could be argued our findings are less likely to be susceptible to confounding by other aspects of trial methodological quality.
Despite clear evidence of improved reporting of several important aspects of trial methods, the quality of reporting remains well below an acceptable level.
They tend to combine assessments of aspects of the quality of reporting with aspects of trial conduct, and to assign weights to different items in ways that are difficult to justify.
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