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In clinical trials, performing and properly reporting randomization techniques, allocation concealment and blinding methods are key to reducing bias and ensuring the validity of study results.57 Among the studies included in our analysis these three aspects of study methodology were the most problematic.
These aspects of study methodology serve to reduce bias and improve generilizability of results.
Although poor reporting of key aspects of study methodology clearly contributes to the problem, other factors such as study conduct, may be equally or more important (Begley and Ellis 2012; Ioannidis 2005; Landis et al. 2012; Tsilidis et al. 2013).
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Here, we detail aspects of the study methodology and report on the baseline social and clinical characteristics of the sample population.
These limitations refer to the clinical aspects of the study methodology rather than specific laboratory techniques that we did not assess.
JM has substantially contributed to all aspects of study design, methodology, and implementation.
EC has substantially contributed to all aspects of study design, methodology, and implementation.
Numerous studies on cognitive aspects of survey methodology have demonstrated that the questions may shape the answers [ 52– 52].
These factors may include the background prevalence of disease in the study population and differences in aspects of the study methodologies, such as inclusion criteria for contacts, time of screening relative to the time of diagnosis of the index case, methods of recruiting contacts for investigation, and diagnostic tests implemented during screening.
Since understanding these differences (and whether they can be reconciled) has important implications for whole-genome association studies, in this article we dissect biases in these estimations that are due to known aspects of study design and analytic methodology.
We examined high-impact journal publications from 2001 to 2010 and extracted data covering authors, institutions, simulation modality, purposes of simulation, and various aspects of study design/methodology used.
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CEO of Professional Science Editing for Scientists @ prosciediting.com