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Methodologies for the rigorous and quantitative evaluation of biological activity or potency are an essential aspect of the developmental pathway for all biologic product candidates.
An adaptive trait is an aspect of the developmental pattern of the organism which enables or enhances the probability of that organism surviving and reproducing.
A third aspect of the developmental hourglass effect is related to the evolutionary age of genes.
In an ideal decomposition, each program would encode a different aspect of the developmental process.
Maternal-infant bonding is one aspect of the developmental process that, successfully achieved, leads to a strong, healthy relationship between mother and infant.
Another aspect of the developmental hourglass is in terms of the significance of each stage for the survival of the embryo.
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But what aspects of the developmental system allow for breaking from constraint?
When such engineered tissues are implanted in vivo they have been shown to induce bone formation by recapitulating aspects of the developmental process of endochondral ossification.
Finely tuned aspects of the developmental programme, specific to one sex, may be more sensitive to specific environmental challenges, particularly during developmental programming and gametogenesis, but also throughout the individual's life, under the influence of sex steroid hormones.
In this study we used the PC12 model to address several key aspects of the developmental neurotoxicity of CPF.
However, as will be shown next, all aspects of the developmental hourglass effect can already be seen with Model-2 (but not with Model-1).
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CEO of Professional Science Editing for Scientists @ prosciediting.com