Exact(9)
Grade 3 event rates were 8% in SHARP compared with 11% in the Asian trial.
The trial included a mix of African and Asian trial sites across a range of malaria transmission settings.
In the African sites only, children aged 6 to 72 months were included in the trial; while in the Asian trial site, older children and adults were included.
Young children in the African and Asian trial sites (aged 6 to 72 months) had fewer deaths with rectal artesunate than with placebo (moderate quality evidence).
Additionally, the complication rate of TACE in our study (88%) was comparable to that of sorafenib reported in the Asian trial (81.9%) [ 7].
The First-Line Single-Agent Iressa Versus Gemcitabine and Cisplatin Trial in Never-Smokers with Adenocarcinoma of the Lung (First-SIGNAL), 21 a smaller Asian trial, obtained results similar to those of the IPASS trial.
Similar(51)
In clinical trials of systemic therapy for advanced hepatocellular carcinoma (HCC), Asian trials almost always reported poorer survival than non-Asian trials.
Sub-group analysis suggested that Asian trials tended to enroll patients with more advanced diseases.
The median survival of patients in the control arm, which indicated natural history of advanced HCC patients, was 3.57 ± 1.88 months in Asian trials and 5.96 ± 1.46 months in non-Asian trials (p = 0.02).
The effects of DP on P. vivax recurrences in the Asian trials with longer follow-up (63 days) was calculated by censoring the data at the time of P. vivax appearance (binary variable).
This meta-analysis included 6 Asian trials and only 1 non-Asian trial.
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