The remaining 259 children were classified as ASD cases.
Of the 676 unrelated ASD cases and 1000 PDx controls, 630 ASD cases (93%) and 896 PDx controls (90%) had at least one rare variant detected on the CGH 1M array (Table 2).
A genome-wide assessment of structural abnormalities in 427 unrelated ASD cases found a microdeletion of 4,289,500bp on 15q23-q24.2 associated with ASD [38].
We analyzed this data set using multidimensional scaling (MDS) as implemented in PLINK (Purcell et al. 2007) to identify a putative group of European ASD cases.
Of the children classified as ASD cases, 94% received ADI-R and 87.6%, ADOS.
Rare (<1% frequency) de novo or inherited copy number variations (CNVs) (especially those that affect genes with synaptic function) are observed in 5 10% of idiopathic ASD cases.
Estimates of ASD regression range from about 15 to 50% of all ASD cases, depending on the definition used.
Although a few percent of ASD cases can be traced to inherited genes, our genes don't change dramatically over the span of just a few decades.
This included all of the ASD cases.
Eighty-eight percent of ASD cases had behavioral regression.
They are thought account for about 10 20% of ASD cases [1], [4], [5].
