A key to ascribing functions to these virulence proteins will be the identification of their host target proteins.
This result has implications for ascribing functions to individual r-protein paralogs in the context of the hypothesis that the cell contains different ribosomes with specialized functions.
A systematic identification of interacting compounds may provide a means to purify more proteins, as well as a method to ascribe function to new proteins.
The idea is that in cases where we can ascribe function to a physiological mechanism the standards of good performance are supplied by nature and not by human values.
This domain lies within the highly conserved Popeye region of the molecule, which heretofore has no ascribed function.
As no previous studies have ascribed function to any motif within Bves, identification of this intracellular domain is critical for an understanding of the function of this molecule.
Without further testing, it is only speculative to ascribe function to any of these polymorphisms.
Whilst it was possible to place most of the trypanosomatid ePKs into the seven established groups using bioinformatic analyses, it has not been possible to ascribe function based solely on sequence similarity.
In contrast, experimental methods to ascribe function, for example using RNAi of single gene products or allelic variants of particular SFP genes, can provide stronger direct evidence for function of specific SFPs but suffer from an inability to handle complex and multidimensional phenotypes [ 19].
A best guess at CRF domain function from a basic analysis of the eight members with a CRF domain that have any ascribed function, would suggest a role in cytokinin regulation, since the six CRFs from Arabidopsis appear to be regulated by that hormone [ 10].
