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The study size was determined based on a priori sample size calculations, and cases were ascertained from provincial cancer registries, except in Quebec where hospital ascertainment was used.
Case ascertainment was passive, relying on self-reporting by intubators on duty in the ED.
Molarius and Tegelberg [28] reported findings similar to ours although their case ascertainment was not based on ICHD-criteria.
Ascertainment was based on an epidemiologic, observational cross-sectional design, and the study was approved by the Institutional Review Board.
Disease ascertainment was incomplete in both arms.
Ascertainment was of unknown bias, precluding formal analyses of inheritance and heritability.
A total of 636 patients had an explained mitral regurgitation, 27 were unexplained, and 19 patients (2.8%) were unclassified because the information available for ascertainment was not sufficient.
The ascertainment was therefore 90.2%.
Case ascertainment was estimated to be 82%.
From January 2002 onward, ascertainment was prospective.
For Quebec, hospital ascertainment was used.
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