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The proposed statistical method can be modified to other population-based family data ascertained from a disease registry provided that the ascertainment process is well documented, and that external information concerning the sizes of birth cohorts and a suitable reference sample are available.
While gaining statistical power by incorporating the ascertainment process in the full likelihood, this study has some clear limitations.
For real data sets, the SNP ascertainment process might also be expected to affect robustness of the approaches.
dRates not calculated for County of Granit because of different case ascertainment process used there; see text for details.
In summary, our study suggests that the ascertainment process may not have a strong impact on accuracy of genomic selection provided SNP density is high enough.
The intensive case ascertainment process yielded a high number of confirmed cases from a variety of clinical settings, unique to ALS surveillance efforts.
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Hence, approaches to perform a separate modeling of the demographic and ascertainment processes have recently been proposed [29].
Differences in case ascertainment processes might explain the observed variation in the proportion of category A Red 1 999 calls (life threatening emergency) reported as cardiac arrest cases.
Zhang and Ji, [ 2005] speculated that autistic children with average cognitive function or mild intellectual disabilities might be neglected during the screening and case-ascertainment process.
Details of the case ascertainment and evaluation process have been previously described [ 1].
The ascertainment and verification process of T2DM cases followed the criteria and procedures defined in the EPIC-InterAct study.
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