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As such, our use of mean telomere length could have resulted in a loss of precision with regard to ascertainment of the shortest telomere length in each cell.
The HCAR is an excellent source of cases because it is (1) population-based, (2) from an ethnically homogeneous, well-defined population, (3) with a high recorded birth prevalence of cases with congenital anomalies compared to other registries (approximately 4%) indicating a nearly complete ascertainment, and (4) the clinical diagnoses have a high level of precision [ 12].
They have the advantage of precision.
"The sense of precision.
There were two conditions of precision demand.
Missing environmental data and a lack of precision in address histories form the primary limitations in GIS exposure assessments, so future studies could be strengthened by the systematic geographic tracking of environmental data and the ascertainment of address histories at the time of reportable diagnoses, such as cancer (Hurley et al. 2003; Wakefield 2000).
It requires a lot of precision.
Cf., with reference to a state tax law assailed as violative of the Fourteenth Amendment, dissent of Mr. Justice Cardozo: 'But profits themselves are not susceptible of ascertainment with certainty and precision except as the result of inquiries too minute to be practicable.
Such data-derived modelling is the preferred method of estimating and comparing screening performance because it can be based on a large enough sample to provide the necessary precision, the sample genuinely represents the population at large, and there are no missing values, with complete ascertainment of clinical events.
Later, he added, "Open hearings are more conducive to the ascertainment of truth".
Incomplete collection and ascertainment of variants demonstrates a need for a universally accessible system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com