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Seizure counts remain an appropriate efficacy endpoint; however, ascertainment in infants and younger children may require EEG monitoring.
Migraine ascertainment in the discovery cohorts was primarily by means of questionnaires, and genotyping was performed utilizing a variety of genotyping platforms.
Conclusions: Variations in maternal mortality ratios reflect different data sources with varying levels of ascertainment in addition to differences in the number of maternal deaths.
It has yet to be recognized in global surveys such as GBD [8 10] because of lack of epidemiological data, itself in part due to difficulties over case definition and ascertainment in population surveys [11, 12].
Given the low ascertainment in all GP clinics, we believe this assumption is reasonable.
Ascertainment in the DISS study has been previously estimated at 86% for type 1 diabetes and 53% for type 2 diabetes [55].
We identify the importance of sensitive and specific case ascertainment in the early phase of a pandemic response, when the proportion of false-positive presentations may be high.
However, a validation study indicated that case ascertainment in our study was at least equivalent to that of other large prospective cohort studies [44].
Ascertainment in the DISS was ~29% for 2007 2009.
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Practical considerations for case-ascertainment in the hospital, as well as the necessary quality control of these programs, are outlined.
Different levels of under-ascertainment in the surveillance system could explain parts of the differences in the incidence.
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