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There were significant geographic challenges in locating and ascertaining data from the subjects in childhood.
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Selection criteria were applied to ascertain data from NH residents older than 65 years old with Alzheimer' disease or other dementia, based on documented medical diagnosis.
A total of 251 newborns with Down syndrome and 396 electively aborted fetuses with Down syndrome were ascertained (data from Czech Congenital Anomalies Register); 61% of pregnancies with Down syndrome are electively aborted [ 22].
This ascertainment corrected version of the likelihood function is also useful in a Bayesian setting, for an example see Katzman et al. [14], where it was used in a Bayesian Hierarchical model for estimating distributions of selection coefficients from divergence ascertained data.
As can be noted visually, very accurate estimates of the unascertained allele frequency distribution are recovered from the divergence ascertained data.
Furthermore, the SEs obtained from bootstrapping the ascertained data are comparable to the full-data bootstrap, suggesting that there is no need to bootstrap the optimal matching step.
Case data were ascertained from the population-based Northern Congenital Abnormality Survey and control data from national data on all births.
Firstly, with the individual matching, it was possible to control primary confounders and to ascertain that data from cases and controls corresponded to each level of the confounders.
In genetic studies of rare complex diseases it is common to ascertain familial data from population based registries through all incident cases diagnosed during a pre-defined enrollment period.
An initial LoS estimate may be ascertained using data from the clinical information system (gray).
Nonfatal myocardial infarction was defined following the World Health Organization Multinational Monitoring of Trends and Determinants in Cardiovascular Disease criteria (23) and ascertained using data from five yearly medical examinations, hospital records of acute ECGs, and use of cardiac enzymes.
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