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The goal of the TIC Genetics study is to undertake a comprehensive gene discovery effort, focusing both on familial genetic variants with large effects within multiply affected pedigrees and on de novo mutations ascertained through the analysis of apparently simplex parent child trios with non-familial tics.
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LB contributed to data analysis and statistical analyses, while JK was responsible for subjects ascertained through the Breast Cancer Family Registry, and helped to revise the manuscript.
Age of depression onset was ascertained through the SCID and review of medical records.
Patients with lung cancer were ascertained through the Genetic Lung Cancer Predisposition Study (GELCAPS).
Deaths occurring through the 1994 data collection phase were ascertained by death certificate; subsequently, mortality and cause of death were ascertained through the National Death Index.
Place of residence on the 1st of January 2009 was ascertained through the Swedish population register (Statistics Sweden).
The UK study included 266 glioblastoma cases ascertained through the INTERPHONE Study (28).
Cases were ascertained through the national registry run by the Association of Paediatric Haematology and Oncology.
The families used in this study were ascertained through the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab).
Deaths occurring in the cohort were ascertained through the Swedish Death Register.
The first cohort (n=1220) consisted of breast cancer patients ascertained through the Rotterdam Family Cancer Clinic.
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CEO of Professional Science Editing for Scientists @ prosciediting.com