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Multiplex families ascertained through multiple alcohol dependent individuals appear to transmit alcohol and drug use disorders at higher rates than randomly selected families of alcoholics.
The variables strength of association with substance use was also ascertained through multiple logistic regression analyses.
We developed a pedigree-based analytical framework to characterise single-nucleotide polymorphism (SNP) associations with BC risk using data from 736 BC families ascertained through multiple affected individuals.
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We found another eight families carrying this mutation in 779 families with multiple cases of breast cancer ascertained through family cancer clinics.
Further screening for PALB2 c.3113G > A (W1038X) was conducted for 779 families with multiple cases of breast cancer ascertained through family cancer clinics in Australia and New Zealand and 764 population-based controls.
Epidemiological, family history and lifestyle data, as well as biospecimens, are collected from multiple-case breast cancer families ascertained through family cancer clinics in Australia and New Zealand.
Breast cancer cases were the youngest affected members of multiple case families (n = 71), ascertained through Family Cancer Clinics by the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer [ 14].
Multiple-case breast cancer families were ascertained through the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer [ 26].
Multiple-case breast cancer families were ascertained through the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) [ 32].
Multiple-case breast cancer families were ascertained through The Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab: http://www.kconfab.org).
We point out that our cohort consists of mutation carriers ascertained through a cancer genetic center, and a majority of them belong to multiple-case families.
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