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Further a biophysical investigation using differential scanning fluorimetry experiments re-ascertained the affinity of these molecules towards the GyrB domain.
Therefore, to confirm such a hypothesis requires significant future work such as building a Nav1.8 homology model and conducting molecular dynamics simulations to ascertain the binding affinity of the [Lys]-fullerene.
In silico molecular modeling methods, such as docking can aid in the drug discovery process by ascertaining the binding affinities of existing and hypothetical compounds towards PfTrxR and the human isoform of this enzyme.
A significant amount of research has been performed to ascertain the features that influence the affinity of specific proteins for membrane microdomains.
The aim of this study has been to verify the efficacy of a verbascoside-based liposomal eyedrops in alkali corneal wound and to ascertain the corneal retention liposomal affinity toward liposomes by modulating their surface charge.
By evaluating non-bonding interaction energies between the inhibitor and the mutant enzymes, we have carried out a mechanistic analysis to ascertain the reasons underlying the decrease in binding affinities.
We also demonstrate their utility as genetic markers for ascertaining the germplasm diversity, genotype individualization, linkage mapping and taxonomic affinities.
To substantiate this observation and to ascertain the specificity of the blocking effect, we tested RBD-variants conthening the R59A mutation which lowers the affinity of RBD for Ras-GTP by about 30fold [ 14, 42].
Although the diachronic data in Chinese and the synchronic data in English have both shown the affinity between the notion of Continuation and Close to Expectation, it requires more direct evidence to further ascertain the relation between the two notions.
'The exercise of ascertaining the facts was a serious one".
Occasionally, Emil made phone calls to ascertain the progress.
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