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However, these studies ascertained cases of cancer among children born in the study area but diagnosed elsewhere.
One potential limitation of our study is that the principal studies quantifying the risk of GBS with influenza illness ascertained cases of influenza in different ways.
The parent SEARCH study (13) has ascertained cases of childhood diabetes among youth younger than age 20 years who were incident in 2002 or later; ascertainment and data collection are ongoing.
For pragmatic reasons in this large cohort study, we included only individuals with clinically ascertained cases of diabetes and thus diabetes status was not determined biochemically, which could lead to presence of undiagnosed diabetes in the cohort.
This dataset ascertained cases of severe preeclampsia as defined by the American College of Obstetricians and Gynecologists [ 44] occurring early-onset (i.e., diagnosis <34 weeks gestation) and matched case (n = 21) and control (n = 21) placentas based on gestational age.
The study population included prospectively ascertained cases of invasive breast cancer diagnosed at 50 years of age or less at 18 treatment centers throughout Poland between 1997 and 2003.
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Studies ascertaining cases of type 2 diabetes by self report involved uncertainty in ascertainment, and thus numbers of cases were revised by a positive predictive value (proportion of verified cases among self reported cases) (see supplementary information and table S3).
Study participants were then followed prospectively for an average of 2.8 years to ascertain cases of first-onset of TMD, and 2,737 provided follow-up data and were considered in the analyses of TMD onset.
Administrative data may lack sensitivity for ascertaining cases of incident clinical vertebral fracture [ 14, 15].
This Program ascertains cases of NTDs annually and maintains an NTD database.
This study compares administrative and survey data for ascertaining cases of IBS.
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