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Strengths of this study include the large sample size of healthy individuals at baseline, from which we ascertained a large number of verified incident cases of type 2 diabetes during 4 million person-years of follow-up.
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To achieve this purpose, we needed a strategy that would feasibly allow us to ascertain a large number of respondents.
Nevertheless previous studies in Europe investigating this possible relationship have been conducted with small sample sizes and thus failed to ascertain a large number of individuals with PWS.
We tried to overcome the methodological limitations of previous studies by ascertaining a large number of incident-verified diabetic case subjects in a cohort of apparently healthy participants at baseline, removing the problem of recall bias.
We ascertained a large Canadian family with a specific pericentral retinal disorder (PRD) (Fig. 3).
We ascertained a large family from Nova Scotia known on a longstanding basis to local corneal specialists.
We ascertained a large Nova Scotia family, as well as four small families, segregating SCCD in a dominant transmission pattern.
Our modeling strategy is illustrated by a risk analysis of type 1 diabetes mellitus (T1D) in the Finnish population-based on the HLA-A, HLA-B and DRB1 human leucocyte antigen (HLA) information available for both ascertained sibships and a large number of unrelated individuals from the Finnish bone marrow donor registry.
Further, we were able to ascertain a relatively large number of cases, and the case ascertainment was highly complete, thanks to matching of the cohort with the national and regional cancer registers.
As it is difficult to interpret variations in management between black and white men diagnosed with prostate cancer, a 'Delphi' consensus approach was used by a panel of experts to ascertain whether management was appropriate for a large number of clinical scenarios in each group.
In those studies, allodynia was retrospectively assessed by the use of simplified questionnaires, which allowed to ascertain that this symptom was present in a large number of migraine children [14].
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