For the individuals who harbored single pathogenic mutations after Sanger sequencing, targeted CNV analysis of the putative causative gene was conducted to ascertain the second allele (category A).
Two families (111, 113) each harbored two different nonsense mutations in DNAH5 and CNV analysis of DNAH5 was conducted using array CGH to ascertain the second allele.
The aim of this analysis was to evaluate the cost, cost-effectiveness, and benefit associated with imatinib, sunitinib, and palliative treatment to ascertain the best second-line therapy option from the standpoint of the national health payer in Mexico, the IMSS.
The study was a mixed-methods design that utilised focus groups, interviews and survey to ascertain the opinions of first exposure to EBL amongst a cohort of first year student midwives.
This system is comprised of an array of closed circuit, infrared-sensitive cameras arranged to constantly monitor individual pregnant females, and allows us to ascertain the delivery of the first pup within a window of five minutes.
The cohort was followed up until 31st December 2006 (allowing a potential minimum of five years and a maximum of 25 years after the initial diagnosis) to ascertain the occurrence of second primary invasive cancers.
This study was therefore carried out to establish the risk of pulmonary embolism associated with antipsychotic drugs, and to ascertain the risk associated with first- and second-generation antipsychotic drugs, and with exposure to individual drugs.
Through the careful control of buffer pH and salt concentration, this assay was then used to ascertain for the first time the relative hydrophobicity values of three different bacteriophage, four mammalian viruses, and a range of biotech medicinal proteins as benchmarked to protein standards previously characterized for hydrophobicity.
A molecular mechanism would be easier to ascertain in the first scenario, but a marker for the trait could be found with either result, i.e., a marker does not need a mechanism to be useful.
