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Complex trait phenotyping can be fruitfully combined with genetical genomic analysis to ascertain the candidate genes and gene product interaction pathways which significantly influence the variation in expression of a phenotype of interest.
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Once candidate genes are identified, functional validation is needed to ascertain the function of the candidate.
Additional experiments must be undertaken to ascertain the involvement of the gene candidates linking PRLR signaling and adipocyte differentiation.
-wrap> The evaluation of GPCR-mediated signaling includes the early response of the MAPK cascade, which has been used in order to ascertain the potential agonist/antagonist activity of novel drug candidates (May and Hill, 2008).
Further work will need to ascertain the true relevance to breast cancer of these candidate genes.
Because groups with 501(c)(4) status were prohibited from making the promotion of a particular candidate or political viewpoint their primary activity, IRS workers attempted to ascertain the degree of political involvement of certain applicants.
In order to ascertain the potential universality of the problems with the 454-only assembly, an analysis of candidate INDELs conflicts from other 454-only genomes sequenced at the JCVI was performed (Table 4).
Presently it is still difficult to ascertain the most ancient class of cGSTs, with theta and omega being the best candidates.
After retrieving functional SSR candidates, CG-SSR provides functional genomics resources GO, InterPro, and Pfam to help users ascertain the potential biological function of each SSR.
All other candidates were contacted by phone for a screening interview, in order to ascertain the capability of engaging in a 1-hour-long interview and the absence of a full-blown mental disorder.
These investigators identified 4 candidate SNPs out of 100 in ENDRA in patients with OSA, but did not ascertain the significance of their findings by haplotype analysis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com