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As various processes could associate microtubule defects and paclitaxel resistance, further studies should ascertain mechanisms that impede microtubule-related cell death initiation in PSP sublines (Davis and Johnson, 1999; Nuydens et al, 2000; Mollinedo and Gajate, 2003).
Why, in light of the wealth of data on clinical observations and the sophistication of tools needed to ascertain mechanisms of sex differences, are there so few current clinical trials based on sex differences research?
Key translational components include voluntary pre-treatment biopsies to identify potential predictive biomarkers post-treatment biopsies to ascertain mechanisms of resistance, and the development of PDX models wherever possible.
In addition to characterization of bacterial virulence apparatuses that are for sure linked to disease outcome, host responses to such factors must also be examined hand in hand, to completely ascertain mechanisms that lead to gastroduodenal disease.
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To ascertain mechanism of RAD21 overexpression in CRCs, we assessed the correlation of gene expression between RAD21 and c-Myc (found on the same amplicon).
To further ascertain, mechanism of anti-diabetic action, we measured the plasma insulin level of the test animals and found no significant increase in insulin secretion on C. asiatica administration, at all doses.
Tour et al. (2011) used graphene and modified graphene materials to stabilize shale formations during drilling operations, but they did not ascertain interaction mechanisms and did not provide experimental data to show the plugging capability of these graphene materials.
An experimental capillary-pumped loop (CPL) was designed to investigate the behavior of phase-change heat transfer devices and ascertain the mechanisms which have caused anomalous behavior of previous CPL demonstrations in low gravity.
New insight provided by a large body of work designed to ascertain the mechanisms underlying the onset of VC has enabled the development of new diagnostic and therapeutic approaches.
It is therefore essential to aim our efforts at trying to ascertain the mechanisms responsible for altering the BBB integrity, and to reduce the process leading to the CNS involvement in SLE.
Subsequent work is required to ascertain the mechanisms by which reduced Smn levels impact upon these pathways.
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