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To achieve this purpose, we needed a strategy that would feasibly allow us to ascertain a large number of respondents.
Nevertheless previous studies in Europe investigating this possible relationship have been conducted with small sample sizes and thus failed to ascertain a large number of individuals with PWS.
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We ascertained a large Canadian family with a specific pericentral retinal disorder (PRD) (Fig. 3).
We ascertained a large family from Nova Scotia known on a longstanding basis to local corneal specialists.
We ascertained a large Nova Scotia family, as well as four small families, segregating SCCD in a dominant transmission pattern.
We have ascertained a large multigenerational family in Nova Scotia affected with SCCD in which we have confirmed linkage to the same general area of chromosome 1.
Strengths of this study include the large sample size of healthy individuals at baseline, from which we ascertained a large number of verified incident cases of type 2 diabetes during 4 million person-years of follow-up.
We tried to overcome the methodological limitations of previous studies by ascertaining a large number of incident-verified diabetic case subjects in a cohort of apparently healthy participants at baseline, removing the problem of recall bias.
Further, we were able to ascertain a relatively large number of cases, and the case ascertainment was highly complete, thanks to matching of the cohort with the national and regional cancer registers.
AS THE world gathers in Copenhagen over the coming weeks to discuss how much carbon dioxide people should be putting into the atmosphere, the Benguela Stream will be docking in the Windward Isles to bring bananas to Europe for Christmas, and doing her bit to help ascertain where a large part of that CO2 ends up.
The data for the health care burden of urinary incontinence are more difficult to accurately ascertain because a large percentage of women and men do not report or access care for urinary incontinence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com