While our results do not as yet define the functional consequences of the MAGE gene mutations observed, they do demonstrate for the first time that this gene family is frequently mutated in melanoma.
In addition to a well-defined biosynthetic pathway, polyamines are internalized into cells by as yet incompletely defined mechanisms.
The optimal dose is as yet not defined.
Although various case reports have associated megadoses with such effects as fatigue, nausea and blurred vision, no definite risks have as yet been defined.
In northwestern and central western Iran, local cultures, as yet barely defined beyond their ceramic parameters, developed in relative isolation from events elsewhere.
Acidic rocks are a significant component of the Cretaceous Paraná Magmatic Province, occurring in different stratigraphic positions, and often forming deposits of complex and as yet poorly defined architecture.
The treaty's Russian backers also reckon that failing to ratify it would undermine candidates in this year's Ukrainian general election who would like their country to join Belarus and Russia in an as yet cloudily defined new Slavic union.Mr Luzhkov and his allies have more fundamental objections.
We find that these variants are identical with each other and differ from the predominant HLA-A2 heavy chain species by a glutamine to arginine substitution at residue 43, by an unidentified substitution in the tryptic peptide spanning residues 147-157, and by an as yet poorly defined alteration in glycosylation.
Rnd3 can down-regulate RhoA.GTP levels by activating p190RhoGAP via an as yet poorly defined binding domain [3]; a complementary mechanism would be to inhibit RhoGEFs such as Syx (Figure 6).
