The cellular and molecular effects of the proteasome inhibitor bortezomib on human skin fibroblasts are as yet poorly characterised.
It is still impossible to interpret comprehensively this overwhelming flood of data and the puzzling complexity of as yet insufficiently characterised molecular networks.
Immediately downstream of Jmjd6 we found the gene 1110005A03Rik, which is predicted to encode a putative methyltransferase, which is as yet not further biochemically characterised.
Fascinatingly, recent studies have uncovered evidence suggesting that in rheumatoid arthritis (RA) such endothelial progenitor cells (EPC) are not only involved in synovial vascularisation, but may also underlie the increased cardiovascular morbidity and mortality known to be a feature of RA, thus linking two features of the disease that are well characterised but are as yet poorly understood.
As an example, characterisation of the immune capability of the koala can inform prophylactic and therapeutic strategies but despite interest in this area there has as yet been only a handful of genes that have been identified and characterised.
Consequently, both murine FLS isolation methods and the resulting cell cultures have yet to be as well characterised as their human counterparts.
The alcyonacean coral L. pauciflorum was further investigated, as NOS had not yet been characterised in soft corals, keystone species in coral reef and other ecosystems.
These pathways may be initiated by specific activation of the two previously cloned receptors as well as those pharmacologically characterised, but not yet cloned (reviewed by Mackie and Stella, 2006).
As the localisation of CD133+ colorectal cancer cells has not yet been characterised in situ, we had to verify that our approach truly detects the CD133 antigen.
Osteoarthritis is thought to be caused by a complex interplay between environmental and genetic factors. 1 As with many common complex disorders, the genetic architecture of osteoarthritis has not yet been characterised.
