Therefore, the relation and distribution of impedance changes within and between defined regions of interest for any given time point, as utilised in the present experimental design, may provide a more robust estimate of ventilation and circulation in different parts of the lung.
A consideration is made of the concept of general conductance as utilised in electrochemical processes and the results of its utilisation are compared with those obtained by using the physical definition of conductance and discussed.
It is likely that the same D-dimer assay, as utilised in our study, could be potentially useful as a means of ruling out PE in pregnant and post-partum patients.
Using the same Heine trial data [ 22] as utilised in this study, Ray et al. [ 29] estimated that exenatide is a cost-effective treatment option in patients with sub-optimally controlled Type 2 diabetes in the UK.
Thus, the dosing schedule as utilised in the model was deemed representative.
The results of the previous ESDM trial [ 13], which used the same dependent measures as utilised in the current design, indicate large effect sizes.
Of interest, this cutpoint also corresponded closely with the median split, as utilised in retrospective reports (Hao et al, 2011; Vaezi et al, 2011b).
Use of standardised PRO questionnaires as utilised in the ZQOL study (e.g. ZBPI and SF-36) may be of value to doctors in clinical practice, both in terms of obtaining symptom and HRQoL reports directly from the patient themselves and also providing patients with a perceived degree of input into their own treatment decisions.
Therefore, in order to make the best-fit curve, we will employ the truncation method as described in the literature, 34 which will exclude all data points less than a particular SNR, generated according to the algorithm described by Bonny et al. 35 For all practical purposes, as utilised in the literature, we will therefore remove data points <2 SNR in our study for short T2* values.
As reported, AZD1152 has been already utilised in a phase I clinical trials in patients with advanced solid tumours, in which this drug showed to induce a significant disease stabilisation, and in phase I/II trials in patients with advanced acute myeloid leukaemia showing an acceptable tolerability profile and an overall clinical response rate of 23% (Lowenberg et al, 2009; Boss et al, 2010).
