MAP6 transcripts are expressed as two isoforms.
The human low molecular weight protein tyrosine phosphatase (HCPTP) is ubiquitously expressed as two isoforms in a wide range of human cells and may be involved in regulating the metastatic nature of epithelial tumors.
DDAH is expressed as two isoforms encoded by different genes.
These proteins are both expressed as two isoforms resulting from the alternative splicing of their pre-mRNAs [1].
PDGF-A exists as two isoforms corresponding to a long (L) and a short (S) form due to alternative splicing of exon 6 [5].
β-arrestin exists as two isoforms, β-arrestin1 and β-arrestin2, both of which are important in the regulation of GPCR desensitization, internalization and signaling events.
These two mRNA sequences were recently merged and annotated as two isoforms of the BMCC1 gene (also called PRUNE2, NCBI Gene ID: 158471).
As previously demonstrated, rat cardiac TnT is expressed as two isoforms, with the lower Mr isoform being highly abundant [22], [23].
The association between BAF and the LEM domain proteins is also conserved between species, as Drosophila BAF interacts with emerin and Bocksbeutel, a LEM domain protein expressed as two isoforms, one lacking the transmembrane domain [33] (Fig. 2).
SYT (SYnovial sarcoma Translocated gene or SS18) is widely produced as two isoforms, SYT/L and SYT/S, that are thought to function in the nucleus as transcriptional coactivators.
ACE is expressed as two isoforms: somatic ACE (sACE), which is responsible for its hypertensive properties, and a smaller isoform (testicular ACE), which is expressed solely in germinal cells.
