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The number of alterations seen in the coded programs increases as tumours progress to more advanced stages.
Thus, apoptotic rates increase as tumours progress.
Several pieces of evidence support the observation that resistance to TRAIL-R signalling increases as tumours progress from benign to advanced, metastatic disease.
Light-scattering spectroscopy uses Mie-theory calculations to recover the average size of cell nuclei, which changes as tumours progress [ 6, 7].
There is an increase in signal transduction protein expression as tumours progress on anti-androgen therapy and in control tumours that are actively growing.
As to our findings in the different colorectal cancer stages, it is possible that the high levels of nuclear oxidative damage found in early stage disease may contribute to this mutator phenotype with a subsequent decline as tumours progress locally.
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In a small study of 21 patients with colonic adenocarcinoma, expression on the vasculature increased as tumours progressed along the dysplasia-carcinoma sequence (Takebayashi et al, 1995).
The effect of treatment with AR and mTOR inhibitors was compared with the addition of an mTOR inhibitor to bicalutamide therapy, as tumours progressed on the anti-androgens.
Later, data demonstrated that as tumours progressed and specific tumour subpopulations were selected or developed, these shed membrane vesicles acquired the ability to suppress cellular immunity (Taylor and Black, 1985 , 1986 Pelton et al, 1991; Gerçel-Taylor et al, 2002; Taylor et al, 2003).
Current hormonal therapies for prostate cancer are effective initially, but inevitably tumours progress to an advanced, metastatic stage, often referred to as 'androgen independent'.
Those patients whose tumours progressed were taken off study as soon as this finding was documented clinically and/or radiographically.
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