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In daily practice, a wider range of patients with prostate cancer (PCa) are selected for active surveillance (AS) compared to those in AS trials, including higher-risk patients.
ASAS40 is a more stringent measure of response than ASAS20 typically used in AS trials.
One optic neuritis event (0.08/100 patient-years), also an SAE, was reported during AS trials.
The proportions of patients with ASAS20 response at weeks 12 and 24 were used as efficacy endpoints in the meta-analysis of AS trials.
Some avoid particular kinds of studies, such as trials for heart drugs or psychiatric drugs.
But as trials began to reach further down the chain of command, soldiers rebelled.
That might indicate the project is running late already as trials were originally slated for September.
Exceptions have included the trial of the boxing promoter Don King, as well as trials of people accused of terrorism.
And trials which gave a favourable verdict are about twice as likely to be published as trials giving unfavourable results.
There is good news on another front as well, as trials of an experimental vaccine begin in Oxford.
Trials with positive results were about twice as likely to be published as trials with negative results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com