The conduct of research and recruitment of children with cancer at the terminal stage is acknowledged as being ethically and technically highly challenging.
GABPα and GABPβ displayed a similar expression pattern during differentiation of white and brown fat cells, with a transient down-regulation at days 1 and 2 (except for GABPα in Rb−/− cells) as well as a second down-regulation at the terminal stages of differentiation (days 6 and 8) (Fig. 5B).
As shown by immunostaining, ORF1p and ORF2p are barely detectable at the terminal stages of mouse oogenesis [ 27, 144].
In high-income countries, the medical advances of recent years have yet to produce a cure, although they have been able to increase the life expectancy and improve the quality of life of the virus carriers, as well as delay the terminal stage of the disease [ 6].
As the disease progresses to the terminal stage, the ability for the person with dementia to meaningfully communicate, ambulate or manipulate objects is severely impaired, if not impossible [ 4].
There are some other types of cancer that may not be curable but are indolent and may take over a decade to progress to the terminal stage, such as thyroid cancer 8– 10.
In late responsive group, total 18 TFs were defined as the key TFs functioning in the terminal stage because of their great changes of RPKM value just beginning from 12 or 24 hours cold stress (Additional file 6), including 3 ARR-B, C3H, 6 CO-like, 2 G2-like, 2 HSFs, 2 NACs and TCP.
As the genetic defect causes a dysfunction in the terminal stage of oxidative metabolism, there is little potential for pharmacological intervention.
As a result, when a patient is in the terminal stage, the patient or family usually requests for discharge from hospital.
When her cancer was discovered, it had already reached the terminal stage.
