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This was before the HTA Programme had the current processes and procedures in place which have developed as the programme matured.
We regularly re-visited the monitoring indicators because, although helpful up to that phase, indicators had to become more sophisticated as the programme matured, reflecting the increasing complexity of the programme [ 15].
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These, together with our external support, permitted the type of light touch management needed to adapt plans and indicators as the programmes matured.
Progress indicators become more sophisticated as the programme matures and capacity is strengthened.
This is a good sign as the project has only been under implementation for about 2 and half years and more lessons may be documented as the programme matures.
The five steps are: i) defining the goal of the capacity strengthening effort, ii) describing the optimal capacity needed to achieve the goal, iii) determining the existing capacity gaps compared to the optimum, iv) devising an action plan to fill the gaps and associated indicators of change, and v) adapting the plan and indicators as the programme matures.
We expect this, as the program matures in the US.
As the ART programme matures, the number of treatment failures to first-line regimens will grow and unless there is the capacity to fund and supervise the use of second-line treatment, the health care system could see a 'rebound effect' of returning AIDS patients.
As ART programmes mature and lessons emerge over time, concern is growing around the challenges of sustaining long-term adherence [23].
This is consistent across all three sub-Saharan regions of Western, Eastern and Southern Africa, and this pattern will be expected to continue and be exacerbated as ART programmes mature and HIV positive patients survive to older ages.
As the planetary exploration programme matures, the objectives for robotic missions become more complex, and place greater demands upon the reliability and robustness of the autonomous systems created for these tasks.
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