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These results contribute to emphasize the importance in providing educational and preventive strategies concerning the risks linked to MOH, such as the probability of developing renal injuries.
The propensity score was defined as the probability of developing AKI-RRT during hospitalization conditioned on the observed baseline covariates and computed using a logistic regression model [ 21].
As the probability of developing advanced fibrosis and hepatocellular carcinoma is significantly greater in patients with steatohepatitis than in those with simple steatosis, it is important to elucidate the mechanism underlying the progression from steatosis to steatohepatitis.
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The utility weight for patients under AS and the probability of developing metastases under AS have the highest impact on model results.
The evaluation of research output, such as the estimation of the probability of developing therapies that can substantially improve health outcomes (so-called breakthrough treatments), is of ethical, scientific, and public importance, but has rarely been assessed systematically.
Sensitivity analysis showed that the probability of developing metastases under AS and utility weights under AS are a major sources of uncertainty.
Several studies postulated the absence of ER expression as an unfavourable factor for the probability of developing BM (Slimane et al, 2004; Weil et al, 2005).
In agreement with our study, a negative hormone receptor status has been identified as significant unfavourable factor for the probability of developing brain metastases in a study of 215 metastatic breast cancer patients [ 18].
During the first 3 years, weight and height were similar in children in the control and late-exposure groups, as was the probability of developing TGCAs (14 vs. 4%; P = 0.1).
The probability of developing multiple islet autoantibodies also was similar between groups (control group: 9.0% by age 3 years; late-exposure group: 8.0%; P = 0.7) (Fig. 4 B ), as was the probability of developing IAAs and GAD antibodies (Supplementary Fig. 1).
We assumed that conditional on the genotype, the age-specific probability of developing a particular cancer was independent of the probability of developing any other type of cancer.
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