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The phrase "as the primary setting" is correct and usable in written English.
It can be used to describe the main location or context in which an event or story takes place.
Example: "The novel unfolds as the primary setting in a small coastal town, where the characters navigate their intertwined lives."
Alternatives: "as the main backdrop" or "as the central location".
Exact(3)
Two of the people responsible for aiding Coogler in realizing his vision for Wakanda, the fictional African nation that the titular hero calls home and serves as the primary setting for the film, are women.
Ueda was chosen as the primary setting of the film because it is located in a territory formerly governed by the prominent Sanada clan, upon which the Jinnouchi family is based.
Many (11/21, 52%) of the interventions were designed to fit within the context of general practice as the primary setting.
Similar(57)
If the game is completed at the Legendary difficulty level, the scene continues to show the piece of Forward Unto Dawn drifting towards an unknown planet, revealed in the sequel to be known as "Requiem", the primary setting of the campaign of Halo 4. Halo 3 was initially conceived before Halo 2 was released in 2004.
The set of particles that gives higher confidence is defined as the primary set and the other one is defined as the secondary set.
He could replace Joe Blanton as the primary set-up man for closer Kenley Jansen.
In total, 2057 unique genes were included across all gene lists, and were used as the primary set of candidate genes.
You may already be familiar with the decadent interiors of Hotel Le Bristol, as it was the primary setting for Woody Allen's film Midnight in Paris.
Meanwhile the new season kept Africa as a backdrop but moved the primary setting to Washington for a fortuitously timed change in administrations, both on the series and in real life.
Patients getting booster vaccinations experienced similar local site reactions as they did when receiving the primary set of vaccines on the pilot study.
The general public population had a similar profile as the primary care setting.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com