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Researchers have been led to suspect non-plaque Aβ oligomers (aggregates of many monomers) as the primary pathogenic form of Aβ.
The synovial membrane, recognised as the primary pathogenic site in RA, has been particularly informative in the study of novel therapeutic agents.
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Although direct cytotoxic effects on endothelial cells by Stx are the primary pathogenic event, there is evidence that indicates the inflammatory response mediated by polymorphonuclear neutrophils and monocytes as the key event during HUS development.
EBV was not the primary pathogenic factor in our samples.
Neutrophils play the primary pathogenic role in GPA [ 13– 15].
The primary pathogenic events in OA include loss and abnormal remodeling of the cartilage ECM.
Note, however, that depending on the context (FAD vs. SAD) the primary pathogenic factors may differ.
The primary pathogenic events in OA include loss and abnormal remodeling of cartilage extracellular matrix.
It has been proved that H2C2O4 is the primary pathogenic material secreted by S. sclerotiorum [ 22- 24].
Glomerular deposition of circulating IgA immune-complexes is considered the primary pathogenic mechanism [ 38].
Coccidioides immitis, the primary pathogenic fungus that causes coccidioidomycosis, is most commonly found in the deserts of the southwestern United States and Central and South America.
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