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Moreover, as the patents of some mAb products expire, development of similar biotherapeutic products (SBPs) is becoming more and more popular (Yoo, 2014; Brinckerhoff and Schorr, 2015; Moorkens et al., 2016).
As the patents of licensed biotherapeutics begin to lapse, there is an increasing interest in developing biosimilars with the same target, mechanism of action, safety, and efficacy as the patented molecules to potentially increase patient access to valuable therapies at lower cost.
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The patenting of protein structures could be as disputed as the patenting of genes.
It has concerns about other recent Internet developments, such as the patenting of web business models and processes, or the potential for abuse by dominant business-to-business exchanges.
It does not, however, prevent specific commercial activities, such as the patenting of human body material in isolated, purified or slightly modified form.
The deal, which had been expected, could help Bristol-Myers plug gaps in its pharmaceutical portfolio as the patents for several of its most profitable drugs begin to expire.
"I have the same problem with this patent as so many of the patents of the dot-com boom days: I don't know what it means," Mr. Goldman said.
Pharmaceutical companies have long complained of ever-rising R&D costs, while being unable to replace the big sellers as they reach the end of their 20-year patents, known as the "patent cliff" – some of the biggest, such as heart medicines Lipitor and Plavix made a combined $14.5bn – yes, billion – in the US market in 2011 alone, yet their patents expired in 2012.
I would expect that WARF would be fairly likely to take a positive approach to making this technology widely available," he said, noting WARF's role as the patent portfolio manager of a leading research university.
As the patent archives grew, the process of searching and validating a patent claim became the domain of experts whose services could be formidably expensive.
As the patent expired in August 2008, the price of the original atorvastatin lowered by 20%.
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