The phrase "as the mutation of" is correct and usable in written English.
It can be used in contexts discussing changes or variations in biological, genetic, or other systems.
Example: "As the mutation of the virus continues, researchers are closely monitoring its effects on vaccine efficacy."
Alternatives: "as the alteration of" or "as the change in".
The ability of VHL to traffic between nucleus and cytoplasm is decreased, even as the mutation of the ubiquitylated site stabilizes VHL.
Mutation of the predicted arginine finger R334 shows the same effects as the mutation of R419, but leads to a less stable Hsp104 oligomer.
However, cancer cells often develop resistance to chemotherapy, which may be drug-specific or mediated by more general mechanisms such as the mutation of p53 suppressor oncogene observed in HT-29 cells (Shao et al, 1996).
T-loop phosphorylation triggers activation of SPAK and OSR1, whereas the role of S-motif phosphorylation is unclear, as the mutation of this residue does not affect SPAK or OSR1 activation [ 7, 11].
Clearly, these data indicate a high structural similarity of chitinolytic and glycan-processing enzymes, since the mutation of W506 of DmFDL led to a similar decrease in activity as the mutation of the corresponding OfHex1 residue.
As the mutation of SCA6 is in CACNA1A encoding Cav2.1, a pore-forming subunit of P/Q-type voltage-dependent calcium channel essential for neurons [ 4, 30, 55], it is possible that such small polyQ expansion leads to neurodegeneration by functional alterations of Cav2.1 [ 5, 14, 21, 28, 35, 36, 50].
Deletion of RNase E is lethal in E. coli and other RNase-bearing bacteria [54], as is the mutation of the key catalytic residues [11].
As for the mutation of Sfpi1, however, there is no direct data about the involvement of radiation in its induction.
Mutation of motif 12 5 had the greatest effect; mutation of only four bp within this motif produced a similar reduction of reporter gene expression as that of the mutation of all three motifs at once.
As expected, the mutation of the catalytically essential cysteine located in the PTP motif 9 abolishes PTP activity of the S/A mutants, confirming typical tyrosine phosphatase activity.
Deletion of the conserved proline-rich region (UAS-EGFP-MenaΔ PRR ), as well as mutation of the F-actin binding domain (UAS-EGFP-MenaΔ FAB ) showed wild-type SSR localization (Fig. 3D-D″,F-F″).
