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The phrase "as the major issue" is correct and usable in written English.
It can be used to highlight a significant problem or concern in a discussion or analysis.
Example: "The report identifies climate change as the major issue affecting global agriculture today."
Alternatives: "as the primary concern" or "as the key problem".
Exact(15)
"I don't see how it can be done," said the director, Michael Blakemore, citing time constraints as the major issue.
What I think has changed is that we are beginning to move on from a situation where women are seen as the problem to one where the culture is seen as the major issue.
The denunciations that followed the report by Mr. Russel of the grand jury decision have gone to what the black community leaders describe as the major issue of the case: racism.
"But it's a very different background than I have, and I think that the people of this country recognize that with our economy as the major issue we face right now that it would be helpful to have someone who understands the economy firsthand, who spent the bulk of his career working in the private sector".
"And I think that the people of this country recognize that with our economy as the major issue we face right now, that it would be helpful to have someone who understands the economy first-hand, who spent the bulk of his career working in the private sector".
Although the improvement in catalytic activity for ammonia oxidation reaction was achieved for some Pt-based electrocatalysts, no effective methods were established to enhance the tolerance toward the catalyst poisoning, which is known as the major issue for the utilization of ammonia as a fuel.
Similar(45)
Economic and information barriers are perceived as the major issues.
He is not lingering on the loss, though, preferring instead to push ahead with what he sees as the major issues coming before Congress.
Our findings show that software practitioners confirm what the literature reports as the major issues that de-motivate them for SPI.
Instead Bachmann went heavy on her local roots and on economics, picking out the price of fuel, the housing market and the national debt as the major issues, while more vaguely bashing the Obama administration on foreign policy and its "unconstitutional healthcare law".
As well as environmental issues, I think the major issue we must address is the high incidence of fatalities.
More suggestions(16)
as the major subject
as the main issue
as the fundamental issue
as the major cause
as the broad issue
as the major theme
as the primary issue
as the major difficulties
as the major themes
as the greatest issue
as the predominant issue
as the principal issue
as the only issue
as the major inspiration
as the major predictor
as the major exposure
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com