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Ferguson-Miller et al. have, indeed, identified residues Glu148, Glu157, Asp195, and Asp214 (all in subunit II of CcO from R. sphaeroides) as the major interaction partners of Cc [ 37].
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HER2/HER3 heterodimers have been described as to be the major interaction in HER2-amplified breast carcinomas [ 36].
Mass spectrometry of the isolated, high molecular, cross-linked stomatin complexes revealed the major interaction partners as glucose transporter-1 (GLUT1), anion exchanger (band 3), and water channel (aquaporin-1).
Interactions noted in the current study that are not listed in any of the major interaction databases, are represented as grey lines.
AGE accumulation has also been reported to worsen endothelial function, and endothelial RAGE has been proposed as the major key in such interaction.
Epistasis has been suggested as one of the major allelic interactions affecting fitness in self-pollinating species such as Arabidopsis thaliana [ 40] and rice [ 41].
The coupling parameter values reveal that the dipolar interaction as the major mechanism.
AGE accumulation may be related to endothelial dysfunction, and endothelial RAGE has been proposed as the major key in such an interaction.
Thus, these drugs were prescribed in accordance with existing best practice even though they would have appeared as major interactions in our series (excluding these patients did not significantly affect the prevalence of patients at risk of CSDIs).
This reflected the significance of water rock interactions as the major source of dissolved ions controlling the chemical composition of these waters (Li et al. 2015; Raju et al. 2015).
These studies indicate a conserved transport pathway of histones H3/H4 that most likely was present in the LECA and implicates HSP90, NASP, Asf1 and Importinβ proteins as the major components as their physical interactions have been described in divergent eukaryotic lineages including ciliates [ 28].
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