Sentence examples for as the main pathogenesis from inspiring English sources

Aggregation of β-amyloid peptide (Aβ), excitatory intoxication, oxidation injury and inflammation reaction are generally regarded as the main pathogenesis for Alzheimer disease (AD).

It is well-known that excessive exposure to glucocorticoids may affect renal excretion and intestinal absorption of calcium, which together with changes in osteoblastic function is regarded as the main pathogenesis of glucocorticoid-induced osteoporosis [ 35].

One review proposed that the overproduction of prostaglandin E2 and leukotriene B4 as well as overexpression of their receptors are major factors in exacerbating inflammation and oxidative stress, which is the main pathogenesis associated with EAC [ 57].

Now, it is assumed that acinar metaplasia could be the main pathogenesis of ACAs based on results of the immunohistochemistry [2].

Increasing evidence supports that the main pathogenesis is inflammation [ 1, 2] and atherosclerosis.

The main pathogenesis is considered to be inflammation in this association.

ROS are implicated in the main pathogenesis of diabetes, rheumatic joint pain, atherosclerosis and hypertension [ 24, 25].

Alteration on ocular surface caused by UV results chronic inflammation, which is the main pathogenesis of pterygium.

We report the first case of uncontrolled splenic hyperperfusion and enlargement with subsequent hypersplenism leading to life-threatening complications of IPH in infancy and show that disease remission after splenectomy in early childhood points to the spleen as the main organ underlying pathogenesis and progression of IPH.

Aβ has been considered as the main culprit in the pathogenesis of AD, resulting in synapse disruption and neuronal destruction.

The recognition of the role of insulin resistance, rather than hyperandrogenism, as the main culprit in the pathogenesis of MetS in PCOS had an important therapeutic implication.