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Pollak has demonstrated what he and others see as the key effect, which may trigger the other benefits of the drug: It inhibits oxygen consumption in mitochondria, in effect turning down the cell's metabolic thermostat.
The NRC considered IUI to be a nonadverse precursor effect but relied on this end point as the key effect in their RfD derivation, treating the lowest dose from Greer et al. (2002) as a no-effect level.
Randomized clinical trials (RCTs) of interventions for the hepatitis C virus have historically used sustained virological response (SVR) at 24 weeks after treatment (SVR24) as the key effect measure.
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Number and duration of quit attempts will be a further outcome measure as it is known that the key effect of advice from a health professional is to encourage the smoker to try to quit [ 10, 11].
As a result, it implies that the key effect of degradation may hide in the second cycle.
Conversely, Ala11 completely lost the ability to interact with TP5 due to the lack of negative residue in its side chain (Fig. 7B, D), which showed that Glu11 acted as a key effect on the binding between TP5 and HLA-DR.
Thus, these data also suggest that statins may cause cell death by autophagy as the key end point effect.
Although the data demonstrate that DHA has no general benefit for AD, a concern remains as to whether the key negative effect may be driven by the failure of ApoE4 subjects to respond.
Additional, work will also need to be done to evaluate whether the CCR3, cdMac, and integrin pathways are interconnected with the EGFR signaling that was known as the key pathway for the effect of cetuximab.
The development of animals with cell-selective knockouts of the AR in various somatic testicular cells points to the Sertoli cell (SC) as the key mediator of the effects of androgens in the control of spermatogenesis.
As I noted yesterday, a key effect of Woodhouse's attack on Steele is the chilling of Republican dissent on the Afghanistan war - Republican dissent that war critics need in order to end it; and the letter attempts to counteract that effect and to pressure the DNC to not engage in this sort of attack on war critics in the future.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com