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Transcriptional network analysis identifies NF-κB, NEMO, Akt, PPARγ and SREBP1 as the key controllers of these processes and suggests that direct regulatory interactions between these factors may govern the transition from early (stressed, inflammatory) to late (pathological, steatotic) hepatic adaptation to HF feeding.
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Owing to the importance of the EBF class of genes as key controllers of the ethylene signal transduction pathway, this study used the apple genome sequence to identify EBF-like genes.
Solid evidence now strongly supports the existence of the once controversial TR cells as key controllers of self-tolerance.
MicroRNAs are small non-coding RNAs that regulate the expression of complementary messenger RNAs and function as key controllers in a myriad of cellular processes, including proliferation, differentiation and apoptosis.
This finding provides insight into the positive regulation of TLR4 signaling and DAMP function, which goes beyond sterile inflammation and defines DAMPs additionally as key controllers of nonsterile inflammation.
Some of them might be as a key controller of a variety of biological phenomenon such as cell differentiation.
After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions including important modulatory activities on the innate and adaptive immune response.
Epithelial cells may be key controllers of the inflammatory response to LPS in the airways.
Transcription factors are key controllers of the signalling cascades activated during development.
The vascular endothelial growth factor (VEGF) cytokine family members are key controllers of angiogenesis and lymph angiogenesis [ 1].
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