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Resveratrol and AICAR experiments appear to be most discriminative for the subgroup classification as the first subclass (subunits) shows low expression in resveratrol and AICAR in patients, and higher expression in AICAR-treated controls (Additional file 2: Figure S6).
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The first subclass includes TLR1, TLR2, TLR4, TLR5, TLR6 and TLR10.
The subclass that includes Bcl-XL binds strongly to Bad BH3 peptide while it has weak binding affinity for the second subclass of Bcl-2 proteins such as Mcl-1 and A1.
The second subclass, E2F4 and E2F5, are referred to as the "repressor" E2Fs because they repress the transcription of E2F target proliferative genes.
The third subclass of F-box proteins are recognized as Fbxo (F-box only) proteins contain no identifiable LRR or WD motifs.
When we used only the mutation data, our supervised analysis of mesenchymal subclass identified IDH1 and TP53 as the first and second ranked candidates.
In the subclass-based ANA test, titers cannot be accurately compared between subclasses, as the second antibodies are different.
This occurs because template 4 belongs to the CC subclass within the chemokine family, whereas templates 1 6 belong to the second, CXC subclass.
To examine the prediction ability of each layer, we evaluated the performance of each RDM type in the EC number prediction individually, where the prediction is performed for the main class (the first digit of an EC number) and the subclass (the first two digits of an EC number) as well as the sub-subclass (the first three digits of an EC number), as shown in Table 2.
A second subclass, the Octocorallia, includes the sea pens, soft "corals", and sea fans.
When we used only the CNV data, our supervised analysis of the proneural molecular subclass compared to all others identified OR51E2 and OR52E4 (chr 11p15) as the second and third ranked candidates; CDK4 was the 17th highest ranking CNV.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com