Sentence examples for as the ddr from inspiring English sources

In addition, as the DDR is tightly regulated in different cell types involving alternative repair pathways, DDR-associated chromatin changes may also be cell-type-specific [ 20, 151].

As the DDR may differ between cell types, siRNA knockdown was used to investigate the impact of PARG dysfunction in a human pancreatic cancer cell line, MIAPaCa2.

Dysregulation of DNA damage repair and signaling to cell-cycle checkpoints, known as the DDR, is associated with a predisposition to cancer and affects responses to DNA-damaging anticancer therapy.

From these initial observations, both teams went on to identify collagen as the DDR ligand, thus attributing for the first time a direct role for the ECM in RTK signalling [16,17].

Moreover, as the DDR activation was impaired in isolated resistant populations, we concluded that RSV anticancer properties highly depended on its DNA-damaging effects and subsequent cancer cell responses.

Since the discovery of collagen as the DDR ligand 15 years ago, steady progress has been made in understanding the structural basis of collagen recognition and signalling by DDRs, but major questions remain.

(One statistic speaks volumes: the Stasi employed five times as many operatives in the DDR as the Gestapo employed in the entire Reich).

In the last 20 years alone, the following states have vanished as political entities: the DDR, the Soviet Union, Czechoslovakia and the Federation of Yugoslavia.

In contrast, low dose of RITA only barely affected the DDR, as did Nut, which correlates with the inefficient apoptosis induction, as evidenced by cleaved PARP levels.. Importantly, the induction of γH2AX by RITA was observed only in the presence of p53, that is, in the p53-positive HCT116 cells, but not in the p53-null HCT116 p53−/−, osteosarcoma Saos2 and lung adenocarcinoma H1299 cells.

However, it can be implemented as a buffer in the DDR, and the consequence is that the computation of hidden polygons may be interrupted a few cycles later.

As the name suggests, the DDR titles, developed by legendary Japanese software house Konami, were foot-heavy stompers, that asked gamers to strut their stuff to a demented soundtrack of low-resolution Jpop.