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For each participant, we refer to the first blood sample as the "baseline" sample (even if collected after onset of illness), and all subsequent samples as "follow-up" samples.
This sample will be referred to as the baseline sample (BA).
In the current study, Wave 2 was used as the baseline sample and Wave 4 (2008/2009) was used as the follow-up sample.
One-thousand bootstrap samples were drawn randomly, conditional on the CFAS design i.e., the marginal totals of people at baseline above and below age 75 within each centre were constrained to be the same as the baseline sample.
Therefore, the impact of IFNB-1b on gene expression profiles was largely based on the difference between baseline and postbaseline samples in the early IFNB-1b cohort and, as the baseline sample was obtained right after the CIS, the impact of the first event could be present in those analyses.
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In columns (2) and (3) of Table 6, we add country fixed effects and controls for education and occupation and see no difference in the estimated coefficients except for the fact that, as in the baseline sample, controlling for education and occupation eliminates the difference between public and private sector.
For the supplementary sample, the same inclusion criteria were applied as in the baseline sample (Sri Lankan nationality, aged 18 65, originally resident in the Northern Province of Sri Lanka, displaced in 1990 and subsequently residing in welfare camps and other settlements in Kalpitiya division of Puttalam district, or born to at least one displaced parent with these characteristics).
One third or two thirds of the liver was removed from each mouse and used as the baseline samples.
PBMC from a single time point within 12 months before the TI were used as the baseline samples.
These are henceforth referred to as the baseline samples and represent potential sources of fish escape to be considered in the assignment simulations conducted herein.
To assess the potential for high-grading bias, the accuracy of among-year IA and MC analyses was also tested using the 28 individuals sampled in 2010 from the same shore (n = 12 individuals) and stream (n = 16 individuals) localities as the baseline sampling from 2007.
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