As already suggested in relation to CONSORT [ 22], we also propose that in their instructions for authors, journals should be more explicit as to the extent to which authors should adhere to specific recommendations.
We cannot exclude a genetic reason for differences between the sexes, such as has been suggested in relation to oestrogen levels in a Hungarian population (Suba, 2007).
This would suggest that the recruitment process was not biased in relation to sex.
As Swinglehurst suggests in relation to patients, health professionals' needs often extend beyond that of receiving evidenced-based information per se, to help in the interpretation and clarification of information especially when there is conflicting evidence [ 1].
It isn't good enough to say the world was different then (as some have been suggesting in relation to the recent crop of historic sex abuse court cases) because there has never been a time when it has been all right to advocate sex with a child.
As Collins et al. suggest in relation to the multiphase optimization strategy framework, '… a full confirmatory trial is mounted only when an optimized intervention has been reached, and only when there is sufficient potential for efficacy (or effectiveness), based on the information gathered in the screening and refining phases' [emphasis in original] (p. 72).
Authors' response: The moderate correlation of miRNA genes and spanion clusters is mentioned as suggested in the 'Relation of spanion clusters and tiRNAs' section.
Furthermore, as suggested by Wendy in relation to socioeconomic position and reiterated by Nazroo and Williams [ 53] and Bhopal et al. [ 54], ethnicity is only one part of a complex web of influences and further research on how these different factors intersect within rehabilitation and self-management specifically is required.
This greater psychosocial burden in low socioeconomic position women may be associated in turn with poorer metabolic outcomes, as suggested in other studies that showed a relation between depression and metabolic syndrome [ 99, 100] and income and metabolic syndrome [ 101, 102].
The relations between the variables, as suggested in the literature, are summarized in a path model.
