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The phrase "as substituted with" is not correct in standard written English.
It is not commonly used and may cause confusion regarding its intended meaning.
Example: "The original ingredient was replaced as substituted with a healthier option."
Alternatives: "as replaced by" or "as exchanged for".
Exact(1)
Five hotspot mutations in the helical and catalytic domain of PI3K were found in 4/49 specimens (8.2%): two were in codon 545 (ID 763 and ID 12458) and 1 in each of codons 546 (already described as substituted with other non synonymous codons, ID 766, ID 767, ID 6147, and ID 12459), 1047 (ID 775), and 1059.
Similar(59)
The aim of the reform was to reduce costs for off-patent pharmaceuticals, through increased price competition, as well as substituting with cheaper equivalents.
Our calculations predict that this reaction becomes increasingly unfavorable as bromides are substituted with phenoxides, as evidenced by the increasing reaction energy of 1.4 < 9.5 < 11.1 kcal/mol.
(3) as (4) and, as so redesignated, substituted "with respect to a member of SIPC filed with a court under paragraph (3)" for "under paragraph (2)" in introductory text and inserted "may," before "with the" in cl.
Restraints may be used to prevent a patient from inflicting self-harm or harming others, she said, but they are meant to be applied for as little time as possible before being substituted with a less restrictive form of control.
There was one concern for Spurs as Vertonghen was substituted with ankle and knee problems.
As proposed, AIEgens substituted with suitable nitro groups can realize unique On Off MRL properties, verifying the validate of our design strategy.
(e) as (d) and substituted "with the Copyright Royalty Judges" for "in the Copyright Office" and "Copyright Royalty Judges shall prescribe as provided in section 803(b)(6)" for "Register of Copyrights shall prescribe".
Similarly, the corresponding increase in iron content as FWSM is substituted with ACM is due to the higher iron content in ACM than in FWSM (Table 3).
Page 3: "As one can get from" has been substituted with "As one can gather from".
Page 5: "as it was well documented" has been substituted with "as it is well documented".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com