Sentence examples for as substantial target from inspiring English sources

Towards the design of new class of podophyllotoxin to target topoisomerase II and tubulin as substantial target in cancer therapy, a series of isoxazolidine podophyllotoxin derivatives were designed.

Thus, as previously suggested [42], PKCγ in the dorsal horn could be a substantial target for preventing the development of tactile allodynia in the clinical setting.

These studies suggest that MOp and MOs share substantial target areas in common33,34,35.

During the last decade, TNFα and IL-6 became widely perceived as substantial therapeutic targets in RA given that the use of either anti-TNFα or anti-IL-6 therapy could successfully control chronic inflammation in RA.

Such studies may also usefully consider the roles in disease of human-specific genes or isoforms (e.g. Nahon 2003; Kitano et al. 2004), as these may provide more substantial targets than SNPs or amino acids for both dysregulation and selection.

Lung constituents such as AECs and endothelial cells are assumed to be substantial targets in BLM-induced apoptosis in vivo [ 13, 36].

"It's definitely in the countries which have substantial increase in consumption – countries like China and India, which are still substantial targets for illegal imports of e-waste," he said.

However, it has long been noticed that AID can be aberrantly expressed in cancer and that its activity is not absolutely restricted to antibody genes, as substantial genome-wide off-target mutations have been observed, which contribute to tumorigenesis and clonal evolution of AID-expressing malignancies.

Results supported selection of production parameters meeting specified quality and cost targets, as well as substantial improvements.

Penalties advertised as "substantial" must bite.

It's as moreish as popcorn, and exactly as substantial.